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Citation: Nizamani N, Al-Abadallah S, El-Zaghrani M, El-Khawaja Y, El-Ibrahim E, et al. "The Quality of Generic Treatment for Depression in the United States: A Synthesis." PLoS ONE. 2011;6(6):e23333. https://doi.org/10.1371/journal.pone.0023333 Editor: Mark O. Himes, The University of Minnesota Medical School, UNITED STATES Received: January 21, 2011; Accepted: May generic pharmacy branches quezon city 3, Published: June 11, 2011 Copyright: © Nizamani et al. This is an open-access generic bupropion vs wellbutrin article distributed under the terms of Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original Promethazine with codeine for sale san diego author and source are credited. Funding: This research was supported by grants from the National Institutes of Mental Health [MH08098 (www.nimh.nih.gov), MM-052680 (www.clinicaltrials.gov)], the National Institute on Drug Abuse (DA006711 (http://www.nida.nih.gov)], the National Institute of General Medical Sciences (G01-GM125570; http://www.grants.nih.gov), the Canadian Institutes of Health Research ( http://www.cihr-irsc.gc.ca is bupropion the generic for wellbutrin ), and the National Institute of Child Health and Human Development (http://www.nichd.nih.gov). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Competing interests: A draft of the manuscript, including abstract, is available under the Copyright Information at PLoS ONE. This does not alter their adherence to all the PLoS ONE policies on sharing data and materials.
Introduction The effectiveness of antidepressants in treating depression is well established (1,2). However, the efficacy of other treatments, such as psychosocial interventions, for this condition is less certain (3). Generic treatment for depression has been proposed as a means for reducing the barriers to treatment by patients and providers alike. As of 2010, the National Institute Medicine (4) identified six antidepressants as "essential medicines" for the treatment of depression and listed bupropion as one of these essential medicines. However, the efficacy and safety of Bupropion 150mg $43.68 - $1.46 Per pill bupropion have only recently been evaluated is bupropion generic for wellbutrin in randomized clinical trials. 2011, the National Institute of Mental Health (5) designated bupropion as one of three essential medicines for the treatment of major depressive disorder. Although the evidence for efficacy of these three essential medicines is promising, generic treatment has only recently been explored as a potential alternative option for reducing the barriers to treatment for patients and providers alike. In a small survey (n = 431) of approximately 70 physicians and 10 medical organizations in North America, Europe, and Australia, the most common barriers to coverage by insurance companies that covered prescription drugs for mental disorders were the cost and lack of availability generic equivalents (6). According to the most frequently cited reason (58%), generic treatment may be more affordable. In a recent report, the FDA found generic bupropion to be as cost-effective (at a median cost of $25,000/year) as the brand version, and to have greater safety, lower gastrointestinal toxicity and abuse liability (7) than the brand version (Table 1). Table 1.
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